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69 results

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Page 1
HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.
Micheli L, D'Andrea G, Leonardi L, Tirone F. Micheli L, et al. J Cell Physiol. 2017 Jul;232(7):1696-1707. doi: 10.1002/jcp.25467. Epub 2017 Jan 27. J Cell Physiol. 2017. PMID: 27333946
PC3/Tis21 is a transcriptional cofactor that inhibits proliferation in several cell types, including neural progenitors. Here, we report that PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells. Furthermore, when HDAC1, HDAC4, or …
PC3/Tis21 is a transcriptional cofactor that inhibits proliferation in several cell types, including neural progenitors. Here, we report tha …
Novel role and regulation of HDAC4 in cocaine-related behaviors.
Penrod RD, Carreira MB, Taniguchi M, Kumar J, Maddox SA, Cowan CW. Penrod RD, et al. Addict Biol. 2018 Mar;23(2):653-664. doi: 10.1111/adb.12522. Epub 2017 Jun 21. Addict Biol. 2018. PMID: 28635037 Free PMC article.
However, the role and regulation of the close family member, HDAC4, in cocaine behaviors remain largely unknown. In this study, we report that cocaine and cAMP signaling in striatum produced differential phosphorylation and subcellular localization of HDAC4 and HDAC …
However, the role and regulation of the close family member, HDAC4, in cocaine behaviors remain largely unknown. In this study, we re …
Specific control of pancreatic endocrine beta- and delta-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9.
Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R. Lenoir O, et al. Diabetes. 2011 Nov;60(11):2861-71. doi: 10.2337/db11-0440. Epub 2011 Sep 27. Diabetes. 2011. PMID: 21953612 Free PMC article.
Analyses of the pancreas of class IIa HDAC mutant mice revealed an increased pool of insulin-producing beta-cells in Hdac5(-/-) and Hdac9(-/-) mice and an increased pool of somatostatin-producing delta-cells in Hdac4(-/-) and Hdac5(-/-) mice. Conversely, HDAC4 …
Analyses of the pancreas of class IIa HDAC mutant mice revealed an increased pool of insulin-producing beta-cells in Hdac5(-/-) and Hdac9 …
Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4).
Li L, Yang XJ. Li L, et al. Methods Mol Biol. 2016;1436:31-45. doi: 10.1007/978-1-4939-3667-0_4. Methods Mol Biol. 2016. PMID: 27246207
In mammals, these enzymes are divided into four classes, with class II further divided into two subclasses: IIa (HDAC4, HDAC5, HDAC7, HDAC9) and IIb (HDAC6 and HDAC10). While HDAC6 is mainly cytoplasmic and HDAC10 is pancellular, class IIa HDACs are dynamically shut …
In mammals, these enzymes are divided into four classes, with class II further divided into two subclasses: IIa (HDAC4, HDAC5, HDAC7, …
Homology modeling and in silico design of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes.
Elmezayen AD, Yelekçi K. Elmezayen AD, et al. J Biomol Struct Dyn. 2021 Oct;39(17):6396-6414. doi: 10.1080/07391102.2020.1798812. Epub 2020 Jul 27. J Biomol Struct Dyn. 2021. PMID: 32715940
Here in this study, we constructed human HDAC5 and HDAC9 protein models using human HDAC4 (PDB:2VQM_A) as a template by the means of homology modeling approach. ...The known inhibitor Rac26 showed the best binding affinity for HDAC5, while TMP269 showed the best bin …
Here in this study, we constructed human HDAC5 and HDAC9 protein models using human HDAC4 (PDB:2VQM_A) as a template by the me …
Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia.
Moreno DA, Scrideli CA, Cortez MA, de Paula Queiroz R, Valera ET, da Silva Silveira V, Yunes JA, Brandalise SR, Tone LG. Moreno DA, et al. Br J Haematol. 2010 Sep;150(6):665-73. doi: 10.1111/j.1365-2141.2010.08301.x. Br J Haematol. 2010. PMID: 20636436 Free article.
ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples. HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL. ...HDAC7 and HADC9 expression levels higher tha …
ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples. HDAC1 and …
Salivary histone deacetylase in periodontal disease: A cross-sectional pilot study.
Liaw A, Liu C, Bartold M, Ivanovski S, Han P. Liaw A, et al. J Periodontal Res. 2023 Apr;58(2):433-443. doi: 10.1111/jre.13104. Epub 2023 Jan 30. J Periodontal Res. 2023. PMID: 36717759
Increased HDAC1 and decreased HDAC9 expression were observed in periodontitis compared to gingivitis. ...HDAC9 showed an acceptable power in discriminating periodontitis from health, gingivitis and non-periodontitis (AUC 0.76-0.80). ...
Increased HDAC1 and decreased HDAC9 expression were observed in periodontitis compared to gingivitis. ...HDAC9 showed an accep …
Class II histone deacetylases: structure, function, and regulation.
Bertos NR, Wang AH, Yang XJ. Bertos NR, et al. Biochem Cell Biol. 2001;79(3):243-52. Biochem Cell Biol. 2001. PMID: 11467738 Review.
Class I members, such as HDAC1, HDAC2, HDAC3, and HDAC8, are well-known enzymatic transcriptional corepressors homologous to yeast Rpd3. Class II members, including HDAC4, HDAC5, HDAC6, HDAC7, and HDAC9, possess domains similar to the deacetylase domain of yeast Hda …
Class I members, such as HDAC1, HDAC2, HDAC3, and HDAC8, are well-known enzymatic transcriptional corepressors homologous to yeast Rpd3. Cla …
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
Macabuag N, Esmieu W, Breccia P, Jarvis R, Blackaby W, Lazari O, Urbonas L, Eznarriaga M, Williams R, Strijbosch A, Van de Bospoort R, Matthews K, Clissold C, Ladduwahetty T, Vater H, Heaphy P, Stafford DG, Wang HJ, Mangette JE, McAllister G, Beaumont V, Vogt TF, Wilkinson HA, Doherty EM, Dominguez C. Macabuag N, et al. J Med Chem. 2022 Sep 22;65(18):12445-12459. doi: 10.1021/acs.jmedchem.2c01149. Epub 2022 Sep 13. J Med Chem. 2022. PMID: 36098485 Free PMC article.
To further investigate the role of HDAC4 in cellular models of HD, we have developed bifunctional degraders of the protein and report the first potent and selective degraders of HDAC4 that show an effect in multiple cell lines, including HD mouse model-derived corti …
To further investigate the role of HDAC4 in cellular models of HD, we have developed bifunctional degraders of the protein and report …
LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and alpha-synuclein-induced degeneration in cellular models of Parkinson's disease.
Mazzocchi M, Goulding SR, Wyatt SL, Collins LM, Sullivan AM, O'Keeffe GW. Mazzocchi M, et al. Mol Cell Neurosci. 2021 Sep;115:103642. doi: 10.1016/j.mcn.2021.103642. Epub 2021 Jun 10. Mol Cell Neurosci. 2021. PMID: 34119632 Free article.
Here we used gene co-expression analysis to identify HDACs that are associated with human dopaminergic (DA) neuron development. We identified HDAC3, HDAC5, HDAC6 and HDAC9 as being highly correlated with the DA markers, SLC6A3 and NR4A2. ...Neither the class I-specific HDI …
Here we used gene co-expression analysis to identify HDACs that are associated with human dopaminergic (DA) neuron development. We identifie …
69 results